Products include some lots of diced yellow onions (3lb bags and 8 oz cups), diced celery and onions (8 oz cups), diced mirepoix (10 oz cups), and diced red onions (8 oz cups). Salmonella enterica subspecies enterica serovar Enteritidis is one of the major foodborne zoonotic pathogens globally. Salmonella enterica serovar Typhimurium, an intracellular pathogen, evades the host immune response mechanisms to cause gastroenteritis in animals and humans. Tim Promkes RSST - RSUP dr. القشعريرة. Salmonella typhimurium DT104 is usually resistant to ampicillin, chloramphenicol, streptomycin, sulfonamides, and tetracycline. Stay hydrated. Acute diarrheal disease remains a major public health issue. Symptoms typically resolve themselves within a week, but if your symptoms persist you will need immediate medical attention. サルモネラ ( Salmonella) は、 グラム陰性 通性嫌気性 桿菌 の 腸内細菌科 の一属( サルモネラ属 )に属する 細菌 。. The latest tweets from @Salmonia3JPApp Detail » Salmonia3. By Michael Levenson. Humans are exposed to the pathogen orally, typically through contaminated food or water. Typical symptoms of Salmonella gastroenteritis include: Diarrhoea, which can sometimes be bloody. enterica. Salmonella enterica serovar Typhimurium is a common facultative intracellular pathogen that causes food-borne gastroenteritis in millions of people worldwide. Of. enterica. The test is performed with rectal swabs and stools, to aid in the diagnosis of Salmonella infections. 1. The first change involves the expanded use of . Almost any food product can be contaminated, but outbreaks are most commonly due to poultry, dairy items such as raw milk, and undercooked eggs. Testing can help guide treatment decisions. People in this outbreak got sick from touching recalled dog food, touching things like dog bowls that contained the dog food, or touching the poop or saliva of dogs that were fed the dog food. Symptoms may be diarrhea, high fever with prostration, or symptoms of focal infection. health officials. Salmon, an American bacteriologist, who first isolated the bacteria from a pig intestine in 1884. Crump, John Wain, in International Encyclopedia of Public Health (Second Edition), 2017 The Organism. Both reptiles and amphibians can carry germs that make people sick. 開発者: Kazuna Asano. Trinomial name. Serotypes are groups within a single species of microorganisms, such as bacteria or viruses, which share distinctive surface structures. E. The T3SS is regarded as the most important virulence factor. Symptoms usually last 4-7 days. - Dolor de cabeza. Although the disease is usually limited to the bowel, and most infected people do not have any serious medical complications, the salmonella germ can spread to other systems of the body, such as the blood and bone. The FDA, along with CDC and state and local partners, are investigating a multistate outbreak of Salmonella Senftenberg infections linked to certain Jif brand peanut butter products. Salmonella usually goes away on its own in a few days. The Centers for Disease Control reported that as of Nov. Resistance continuously emerges. Salmonellosis, colon, horse. Less frequent, but fairly common symptoms include nausea, vomiting, loss of appetite, and headache. infection is one of the leading causes of acute diarrheal disease despite the preventive measures implemented. MINNEAPOLIS — Two people in Minnesota died after they got sick with Salmonella from pre-cut cantaloupes. 4 million people are infected with Salmonella each year []. Forty-five people have been hospitalized, and two have died. This sample came from a papaya from the farm Productores y Exportadores de Carica Papaya de Tecomán y Costa Alegre in Tijuana, Baja California, Mexico. Este artigo é sobre a bactéria. The Salmonella bacteria is a Gram-negative, motile, hydrogen sulfide producing, an acid-labile facultative intracellular microorganism that commonly causes gastroenteritis worldwide and causes cross. Outbreak Linked to Dry Dog Food. We would like to show you a description here but the site won’t allow us. The Salmonella germs may get into the food you eat in several ways. Salmonella species can infect a diverse range of birds, reptiles, and mammals, including humans. Dolor de cabeza. These germs can spread from the birds to their eggs. S. 5, was. Some people—especially children younger than 5 years, adults 65 years and older, and people with weakened immune systems—may. Another species, Salmonella enteritidis, has been associated with foodborne diseases resulting from consumption of contaminated undercooked eggs. Several brands of whole and pre-cut cantaloupes and pre-cut fruit have been recalled. In most cases, salmonella is a brief illness that causes stomach cramps and diarrhea for a few days. Salmonella consists of only two species, namely Salmonella enterica and Salmonella bongori . S. Salmonella is the name of a group of bacteria. and Canada have been sickened by salmonella after eating cantaloupe or additional fruits and brands under recall. 1:10. Para a doença causada por salmonelas, veja. You’ll be able to access the builds that the developer makes available to you. Take a look at these five facts and CDC’s tips for lowering your chance of getting a Salmonella infection. Wash your hands after handling a chicken or collecting eggs and do so either outdoors or using a sink that isn't used for food preparation. Use-by dates between August 8, 2023, and August 28, 2023. After invading the host cells, the bacteria proliferate in Salmonella-containing vacuole (SCV) and escapes from antimicrobial therapy. Salmon, an American bacteriologist, who first isolated the bacteria from a pig intestine in 1884. Because salmonella infection can cause dehydration, treatment focuses on replacing lost fluids and electrolytes — minerals that balance the amount of water in the body. Infected individuals may develop an asymptomatic infection,. Lo que necesita saber. Causes, symptoms, risks, treatment, prevention, surveillance information and guidance for health professionals. Most people recover within 4 to 7 days without treatment. TYPHI) Shape – Salmonella typhi is a rod shape (bacillus) bacterium. Salmonella can be found in many foods, including sprouts and other vegetables, eggs, chicken, pork, fruits, and even processed. Arizona, Missouri, Minnesota, Wisconsin and Ohio have the highest number of cases. The two known species of Salmonella are Salmonella enterica and Salmonella bongori. Courtesy of Dr. Salmonella. [1] The Salmonella bacteria is a Gram-negative, motile, hydrogen sulfide producing, an acid-labile facultative intracellular microorganism that commonly causes gastroenteritis worldwide and causes cross-infection between humans and animals. Salmonella is a Gram-negative bacterial genus of the Enterobacteriaceae family with a strong pathogenicity that can cause cross-infection between humans and animals. 0:56. Salmonella stands out among pathogenic organisms for its high prevalence. Discussion. Salmonella prevention tips during pregnancy. We would like to show you a description here but the site won’t allow us. Serotyping and multilocus sequence typing (MLST). Here are 20 interesting facts about salmonella: 1 This organism is named after a pioneering American veterinary scientist – Daniel Elmer Salmon, who discovered the bacteria in 1885. There is a wide range of sources of Salmonella infection, eggs, meat, dairy products, vegetables and water are the most important. Salmonella. enterica and S. 0:23. The severity of the disease will often determine the signs and symptoms that are overtly present in the cats. S. CDC. Salmonella causes fever, diarrhea, gastroenteritis,. Vinyard: Consumers may obtain additional information by calling Jennifer Vogler at 1-405-639-2451, Monday through Friday 9 a. Salmonia3のアップデート開発状況 Swift SwiftUI ハズブロ ボードゲーム モノポリー クラシック C1009 正規品 価格 ¥1,367 Salmonia 先週末にリザルトアップ. Salmonella is named after D. THE NCBI Taxonomy database allows browsing of the taxonomy tree, which contains a classification of organisms. 1 2 The overall incidence of Salmonella positive urine cultures has been estimated to be between 0. Su proveedor de salud puede diagnosticarla con una prueba de heces. enterica is the type species and is further divided into six subspecies [2] [3] that include over 2,600 serotypes. Introduction. Treatment for a salmonella infection usually starts with home remedies and over-the-counter medications. Salmonella stands out among pathogenic organisms for its high. 17 EST. Salmonella enterica has over 2,000 strains. At present, the only licensed live oral attenuated salmonella vaccine is Ty21a, (produced using chemical mutagenesis). Salmonella är ett variationsrikt släkte bakterier i familjen Enterobacteriaceae. . Salmonella is a widely distributed foodborne pathogen. Eggshells can also become. Note that, in addition to cantaloupe sold by ALDI, the affordable grocery chain has also recalled pineapple spears that may have been cross-contaminated with cantaloupe. Reports of Salmonella isolates from animals and related sources (e. This genus only contains two species, Salmonella bongori and Salmonella enterica. Salmonella is an enteric pathogen belonging to the family Enterobacteriaceae. Salmonella enterica has over 2,000 strains. Salmonella is one of the most frequently isolated foodborne pathogens. Bacterial-mediated cancer therapy (BMCT) has become a hot topic in the area of antitumor treatment. Recalled onions were sold in select stores and were also. health officials recalled three more brands of whole and pre-cut cantaloupes Friday as the number of people sickened by salmonella more than doubled this week. In humans, the most common symptoms are diarrhea, fever, abdominal cramps. Salmonellae cause a number of clinical infections in humans; these include: Gastroenteritis. Traceback determined that Wismettac Asian Foods, Inc. Antibiotics are typically used only to treat people with severe illness. Nearly 100 people in 32 states. Symptoms usually last 4-7 days. The introduction of antimicrobial agents and Salmonella-specific phages has been considered as an effective intervention strategy to reduce Salmonella contamination. 1 Background of Salmonella enterica infection in humans. Symptoms typically last for about four to seven days but may linger as long as several weeks. 6. 63% of all Salmonella infections in large retrospective reviews. 2–5. Many of the pathogenic serovars of the S. To verify if a recently developed small-molecular inhibitor of T3SS FT. Itämisaika on 6–72 tuntia. Salmonella bacteria cause infections via fecal-oral transmission. Pet food can sometimes be the source of Salmonella infection. 8. Salmonella is a Gram-negative, rod-shaped, motile bacilli that moves with the use of its peritrichous flagella. S. Ikuko Kato, in Progress in Molecular Biology and Translational Science, 2020. Children younger than 5 years old are most likely to get salmonellosis. Food and Drug Administration (FDA) investigated a multistate outbreak of Salmonella Enteritidis infections linked to peaches packed or supplied by Prima Wawona or Wawona Packing. Sulfonamides. and Canada. Salmonella illness is more common in the summer. Steps in laboratory testing and reporting Salmonella infection . enterica subspecies enterica (also known as subspecies I). ›. Of. coli and Shigella, it’s one of several organisms in the Enterobacteriaceae family. Salmonellosis is a disease caused by the bacteria called Salmonella. Tem, em seu nome, uma referência ao cientista estadunidense chamado Daniel Elmer Salmon, que associou a doença à bactéria pela primeira vez. Typhimurium), C (example - S. You may be one of the many Americans who owns a pet reptile or amphibian. Salmonella bongori har främst setts hos reptiler. S. Salmonella typhimurium has been the species that accounts for most foodborne illnesses related to this bacteria. Salmonella spp. Prevention. Salmonella spp. S. Published by: Kazuna Asano + Universal App - Designed for iPhone and iPad Price: FREE! Current Version: 0. Enteritidis, S. So far, only. Nontyphoidal salmonellae are gram-negative bacteria that primarily cause gastroenteritis, bacteremia, and focal infection. 88 ID:aH/INL5kM. 1. First the "O" antigen type is determined based on oligosaccharides. Salmonella ranks high among the pathogens causing foodborne disease outbreaks. Seseorang yang terinfeksi bakteri Salmonella dapat mengalami gejala berupa demam, diare, dan kram perut selama 4–7 hari. Vaccines have been developed to reduce the disease burden at the pre-harvest stage, but the cell-mediated immune response against intracellular invasion of the pathogen is not sufficiently elicited by conventional. アインホホ専用?. Salmonella er en af de mest almindelige årsager til smitsomme infektioner i mave-tarm. القيء. Every year, approximately 40,000 cases of salmonellosis are reported in. ファイルをコンピュータにダウンロードする場合は、必ずそれをあなたのAndroidデバイスに移動してく. I 2015 var antallet af smittede 925 i Danmark – det laveste antal i 30 år. 19 Part of the reason for their lack of use in at-risk. The recalled products were sold in the U. Many animals and pets can carry these germs, even if they look clean and healthy. The horizontal acquisition of SPI-1 by the common ancestor of all Salmonella is considered a prime example of how gene islands. Fresh beef, veal, lamb steaks, roasts and chops, as well as fresh pork and ham, should be cooked. Diarrhea; Fever; Abdominal cramps; How long does the illness last? The illness usually lasts 4 to 7 days, and most people recover without treatment. Outbreak at a glance. Humans are exposed to the pathogen orally, typically through contaminated food or water. Salmonellae are motile gram-negative bacilli that infect or colonize a wide range of mammalian hosts. The Centers for Disease Control announced Friday that two people have died and 28 more people have been hospitalized in a salmonella outbreak in cantaloupes across 32 states. A salmonella infection (salmonellosis) can be contracted from food, pets, or exposure to human or animal feces. 12,593 likes · 75 talking about this · 10,726 were here. The main niche of Salmonella serovars is the intestinal tract of humans and farm animals. It is divided into six subspecies, arizonae (IIIa), diarizonae (IIIb), houtenae (IV), salamae (II), indica (VI), and enterica (I). What Is Salmonella in Dogs? Salmonella is a type of bacteria that infects the gastrointestinal tract and can cause severe diarrhea in humans. FT inhibits SPI-1 effector proteins secretion and replication salmonella induced by SPI-2 in peritoneal macrophages in vitro. Salmonellosis is the second most common zoonotic disease after campylobacteriosis in the EU, and Salmonella is a common cause of foodborne disease outbreaks. 発売日: 2023-03-04. Both domestic and wild animals can carry this bacteria, and it can be found in pigs, cows, and rodents. Karen L. 015% and 0. Additionally, Salmonella bacteria have evolved multiple mechanisms to avoid or subvert immunity to its own benefit and often the anatomical location of. In the EU, over 91,000 salmonellosis cases are reported each year. In 2014, the U. There have been 26 confirmed Canadian cases, seven in Ontario, of salmonella linked to the outbreak. Salmoneloza je bakterijska infekcija tankog i debelog crijeva. For instance, Salmonella bacteria look alike under the microscope but can be separated into many serotypes based on two structures on their surface: The outermost portion of the bacteria’s surface covering,. Typhoid fever is a systemic infection caused by the bacterium Salmonella enterica subspecies enterica serovar Typhi (Salmonella Typhi) and is an important cause of illness and death worldwide, with an estimated 10. The Food and. py","path":"tools/convert_db. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Contents. Salmonella is a major causative agent of foodborne illness and rapid identification of this pathogen is essential to prevent disease. Salmonellosis is infection with Salmonella spp bacteria. An Atlas of Salmonella [PDF – 248 pages] is the first-of-its-kind report that charts over 40 years of laboratory-confirmed surveillance data on 32 Salmonella serotypes. There are over 2500 different types of the bacteria. 3; Released: March 18, 2021; CDC estimates Salmonella bacteria cause about 1. E. 23 hours ago · Logout. 取り込み終了判定は「取り込んだ件数=リザルト件数. Salmonella är ett variationsrikt släkte bakterier i familjen Enterobacteriaceae. Refrigerate leafy greens within 2 hours. S. Arrangement Of Cells – Salmonella typhi is arranged singly or in pairs. health officials recalled three more brands of whole and pre-cut cantaloupes Friday as the number of people sickened by salmonella more than doubled this week. Bakteri ini juga sering menyebabkan keracunan makanan. Diagnosis is by cultures of blood, stool, or site specimens. There are two widely-available forms of vaccine licensed for use against Salmonella, 17, 18 yet neither have been implemented at country level. They are a common cause of foodbor. Salmonella fact sheet. The use of Salmonella phages as biocontrol agents has recently gained significant interest. Salmonella enterica subsp. enterica. If you are handling or preparing food, it is important to thoroughly wash your hands with soap and warm water before and afterward. Alongside the likes of E. ファイルサイズ: 32. AUSTIN, Texas — Health officials are urging people not to eat certain cantaloupes and pre-cut food dishes as an. Salmonella alone accounted for 33% of these outbreaks. John Prescott. You can get a Salmonella infection from a variety of foods, including chicken, turkey, beef, pork, eggs, fruits, sprouts, other vegetables, and even processed foods, such as nut butters, frozen pot pies, and stuffed chicken entrees. S. - Escalofríos. U. S. gov. อ่าน 24 รีวิวคุณภาพและเมนูแนะนำโดยผู้ใช้ Wongnai จากร้าน Salmonia (แซลมอนเนีย) Avion Village ซ. The most common type of infection is the carrier state, in which infected animals carry the. Los huevos son uno de los alimentos más. “La salmonela tiene una gran capacidad de adaptación. HOUSTON — Fresh cantaloupes sold in Texas and at least 32 other states are blamed for salmonella poisoning that's made nearly 100 people sick and caused two deaths. While most people recover completely on their own, some people may have a more serious illness that: requires hospital care. Most people who get salmonellosis will have diarrhea, fever, and abdominal cramps. 4. Infection is diagnosed when a laboratory test detects Salmonella bacteria in stool, body tissue, or fluids. Some types of sprouts, like alfalfa, are also a. In some kids, it causes a headache. ב טבע קיימים מאות תת-מינים ואלפי סרוטיפים( אנ') של חיידקי ה- Salmonella. Salmonella accounted for the most hospitalizations (64%) in outbreaks with a confirmed cause 6. Here, five Salmonella phages were isolated from. - Releases · tkgstrator/Salmonia. E. CHROMagar™ Salmonella is a selective chromogenic culture medium intended for use in the qualitative direct detection, differentiation, and presumptive identification of Salmonella. Some people can become very unwell with dehydration. To date, over 2500 Salmonella serotypes have been identified and more than half of them belong to Salmonella enterica subsp. By Coral Beach on November 16, 2023. Salmonella spp. Si consume huevos crudos o poco cocidos, puede enfermarse. The number of people nationwide who have been sickened by contaminated cantaloupe has doubled in the last week. # Salmonia3. Why New Vaccines against Salmonella are Needed. The clinical picture of salmonellosis varies from a common gastroenteritis to enteric fevers which are life-threatening diseases requiring a prompt and correct antibiotic treatment. Drink plenty of fluids, especially water, and sports drinks that contain electrolytes. 24 (UPI) --A salmonella outbreak linked to cantaloupes and pre-cut fruit has caused 45 hospitalizations and two deaths, the CDC says. Salmonella infections are diarrheal infections caused by the bacteria salmonella. SALMONELLA 28 de febrero de 2013 1. S. In developed countries, Salmonella usually causes a gut infection called gastroenteritis or food poisoning. being sick (vomiting) stomach cramps. However, some people do not develop symptoms for several weeks after infection and others experience symptoms for several weeks. An outbreak of 25 culture-confirmed cases of multidrug-resistant S. Su proveedor de salud puede diagnosticarla con una prueba de heces. 63% of all Salmonella infections in large retrospective reviews. Mumy, in Reference Module in Biomedical Sciences, 2023 Abstract. 19, 2021 — The U. RESISTANT . 744: スプラ大好き名無し 2022/11/18 (金) 20:00. The majority of Salmonella that infect cattle are in groups B (species example - S. Pet food can sometimes be the source of Salmonella infection. Recalled Food. Abstract. Chickens and other live poultry can carry Salmonella bacteria. Download. For a more complete list of outbreaks involving Salmonella, use the National Outbreak Reporting System (NORS) Dashboard. According to a study, salmonellosis is more common in women than men in mid- to older age groups. 36 percent per annum. Salmonellosis is a disease caused by the bacteria Salmonella. You can get sick when you touch your mouth with unwashed hands after touching wild birds, bird feeders or bird baths, or your pets that. Salmonella. They are generally motile and grow on standard laboratory media, such. 015% and 0. Nearly 100 people in 32. Ninety-nine cases related to the outbreak have been. Until recently, traditional serology and the Kauffmann White Scheme (KWS) have been the gold standard for Salmonella serotyping. health officials are warning consumers not to eat certain whole and cut cantaloupes and pre-cut fruit products linked to an outbreak of salmonella poisoning. Fortunately, you can reduce your risk of getting salmonella when you're pregnant by taking a few simple steps: Thoroughly cook your meats. bongori, diversity lies in the over 2,000 serovars that comprise S. Symptoms of salmonellosis are. Vinyard. Soeradji Tirtonegoro Klaten. They have peritrichous flagella, although they are sometimes nonmotile. Salmonia3+ is a result management application dedicated to Salmon Run NEXT WAVE of Splatoon3! App Details Version 2. Several brands of cantaloupe — both whole melons and pre-cut, packaged products including some mixed fruit — have been recalled due to a salmonella outbreak. National Center for Emerging and Zoonotic Infectious Diseases. According to a study, salmonellosis is more common in women than men in mid- to older age groups. As you cope with the symptoms of a. Clinical data suggested reduced effectiveness of quinolone therapy in patients with nalidixic acid-resistant Salmonella strains. 互換性: iOSが必要です 15. Suoliston salmonellainfektion yleisimmät oireet ovat ripuli ja kuume. In this investigation, whole-genome sequencing was employed to determine the antimicrobial resistance (AMR) pattern of a collection of Salmonella Enteritidis isolated. Contribute to tkgstrator/Salmonia3 development by creating an account on GitHub. แซลมอนเนีย บุฟเฟ่ต์แซลมอน เปิดบริการทุกวัน 11:00-21:30Salmonella is the name of a group of bacteria. 1 day ago · U. 5% of all isolated strains belonging to S. Salmonella is a bacteria that can cause illness to people. First discovered by an American scientist named Dr. SALMONELLA. 主に動物の 消化管 に生息する 腸内細菌 の一種であり、その一部はヒトや動物に 感染 して 病原性 を示す。. As chicken meat is a good reservoir for Salmonella, it is. Salmonella fact sheet. La Salmonella es una bacteria que puede enfermarlo. Whole Genome Sequencing (WGS) has now emerged as an alternative in this field. Salmonella is a Gram- negative, rod-shaped bacterium. The Centers for Disease Control says that 99 people across 32 states (map) have been. Nov. Updated: Nov 24, 2023 / 12:32 PM MST. coli and Shigella, it’s one of several organisms in the Enterobacteriaceae family. People who have weakened immune systems, along with young children and older adults are more likely to get sick with a Salmonella infection. This highly ubiquitous species consists of more than 2600 different serovars that can be divided into typhoidal and non-typhoidal Salmonella (NTS) serovars. It’s one of the most common types of food. Don’t let Salmonella make you or your loved ones sick. Salmonellosis is an infection with a bacteria called Salmonella, Salmonella live in the intestinal tracts of animals, including birds. vomiting, in some cases. (Image credit: Shutterstock) Salmonella is a group of bacteria that commonly cause a foodborne illness. At least 17 people in more than a dozen states were hospitalized with salmonella poisoning linked to recalled whole and pre-cut fruit. Salmonellae cause a broad range of infections, including gastroenteritis, enteric fever, bacteremia, endovascular infections, and focal infections such as osteomyelitis and abscesses [ 1 ]. 12,593 likes · 75 talking about this · 10,726 were here. Salmonella (ב תעתיק ל עברית: סלמונלה) הוא סוג של חיידק אמיתי, גראם-שלילי, בעלי צורה מתגית השייך ל משפחת ה-Enterobacteriacea. If you have symptoms of salmonella poisoning, try to rest and drink clear liquids to prevent getting dehydrated. At least two people in Wisconsin have been hospitalized and two other Wisconsinites have fallen ill from a salmonella outbreak linked to contaminated cantaloupes suspected to have sickened. Nearly. They were caused by a variety of pathogens, and 106 of them were confirmed Salmonella. Most people with salmonellosis develop diarrhea, fever, and abdominal cramps. are unable to keep fluids down. 1. Birds can carry germs like Salmonella while looking healthy and clean. Salmonella . Symptoms may be diarrhea, high fever with prostration, or symptoms of focal infection. There are more than 2,500 strains of salmonella bacteria. enterica. Salmonella is a group of bacteria that can infect animals and humans. Salmonella is a genus of rod-shaped (bacillus) gram-negative bacteria of the family Enterobacteriaceae. In addition to the above nonmotile salmonellae, Salmonella paratyphoid infections in poultry are relatively common and have public health significance because of contaminated poultry product consumption. Some species exist in animals without causing disease symptoms, while others can result in any of a wide range of mild to serious. 1. October 20, 2021. Millions of households in the United States own at least one reptile (like a turtle, lizard, or snake) or amphibian (like a frog, salamander, or caecilian). Der er flest syge i sommerhalvåret med størst forekomst i august. Causes of Salmonella Infection. Salmonella é um gênero de bactérias, vulgarmente chamadas salmonelas, [1] pertencente à família Enterobacteriaceae, sendo conhecida há mais de um século. typhi, which causes systemic infections and typhoid fever, yet is very host specific and will only infect humans, killing an estimated 500,000. S. Kids with a infection typically have diarrhea (sometimes with blood in it), fever, and belly pain. 1 day ago · The Associated Press. Stomach cramps.